Gypsum is an evaporite mineral most commonly found in layered sedimentary deposits in association with halite, anhydrite, sulfur, calcite, and dolomite. Gypsum (CaSO 4. 2H 2 O) is very similar to Anhydrite (CaSO 4). The chemical difference is that gypsum contains two waters and anhydrite is without water. Gypsum is the most common sulfate mineral.